David Benjamin Goldstein

missing portrait

Richard and Pat Johnson University Professor of Cardiovascular Genomics

External address: 
330 LSRC B-wing, Durham, NC 27708
Internal office address: 
Duke Box 91009, Durham, NC 27708-1009
Phone: 
(919) 684-0896

Education

  • Ph.D., Stanford University 1994

Altman, RB, Flockhart, D, Goldstein, DB, Altman, RB, Flockhart, D, and Goldstein, DB. Principles of pharmacogenetics and pharmacogenomicsPrinciples of pharmacogenetics and pharmacogenomics (PublishedPublished). January 1, 2012. Full Text

Altman, RB, Flockhart, D, and Goldstein, DB. "Introduction."xi-xii. January 1, 2012. Full Text

Walley, NM, Nicoletti, P, and Goldstein, DB. "Pharmacogenetics." In Vogel and Motulsky's Human Genetics: Problems and Approaches (Fourth Edition),635-647. January 1, 2010. Full Text

Black, HA, Leighton, DJ, Cleary, EM, Rose, E, Stephenson, L, Colville, S, Ross, D, Warner, J, Porteous, M, Gorrie, GH, Swingler, R, Goldstein, D, Harms, MB, Connick, P, Pal, S, Aitman, TJ, and Chandran, S. "Genetic epidemiology of motor neuron disease-associated variants in the Scottish population." Neurobiology of Aging 51 (March 2017): 178.e11-178.e20. Full Text

Schoch, K, Meng, L, Szelinger, S, Bearden, DR, Stray-Pedersen, A, Busk, OL, Stong, N, Liston, E, Cohn, RD, Scaglia, F, Rosenfeld, JA, Tarpinian, J, Skraban, CM, Deardorff, MA, Friedman, JN, Akdemir, ZC, Walley, N, Mikati, MA, Kranz, PG, Jasien, J, McConkie-Rosell, A, McDonald, M, Wechsler, SB, Freemark, M, Kansagra, S, Freedman, S, Bali, D, Millan, F, Bale, S, Nelson, SF, Lee, H, Dorrani, N, Goldstein, DB, Xiao, R, Yang, Y, Posey, JE, Martinez-Agosto, JA, Lupski, JR, Wangler, MF, and Shashi, V. "A Recurrent De Novo Variant in NACC1 Causes a Syndrome Characterized by Infantile Epilepsy, Cataracts, and Profound Developmental Delay." American journal of human genetics 100, no. 2 (February 2017): 343-351. Full Text

Shashi, V, Pena, LDM, Kim, K, Burton, B, Hempel, M, Schoch, K, Walkiewicz, M, McLaughlin, HM, Cho, M, Stong, N, Hickey, SE, Shuss, CM, Freemark, MS, Bellet, JS, Keels, MA, Bonner, MJ, El-Dairi, M, Butler, M, Kranz, PG, Stumpel, CTRM, Klinkenberg, S, Oberndorff, K, Alawi, M, Santer, R, Petrovski, S, Kuismin, O, Korpi-Heikkilä, S, Pietilainen, O, Aarno, P, Kurki, MI, Hoischen, A, Need, AC, Goldstein, DB, and Kortüm, F. "De Novo Truncating Variants in ASXL2 Are Associated with a Unique and Recognizable Clinical Phenotype." American journal of human genetics 100, no. 1 (January 2017): 179-. Full Text

Appenzeller, S, Balling, R, Barisic, N, Baulac, S, Caglayan, H, Craiu, D, De Jonghe, P, Depienne, C, Dimova, P, Djémié, T, Gormley, P, Guerrini, R, Helbig, I, Hjalgrim, H, Hoffman-Zacharska, D, Jähn, J, Klein, KM, Koeleman, B, Komarek, V, Krause, R, Kuhlenbäumer, G, Leguern, E, Lehesjoki, A-E, Lemke, JR, Lerche, H, Linnankivi, T, Marini, C, May, P, Møller, RS, Muhle, H, Pal, D, Palotie, A, Pendziwiat, M, Robbiano, A, Roelens, F, Rosenow, F, Selmer, K, Serratosa, JM, Sisodiya, S, and Stephani, U et al. "De Novo Mutations in Synaptic Transmission Genes Including DNM1 Cause Epileptic Encephalopathies." The American Journal of Human Genetics 100, no. 1 (January 2017): 179-179. Full Text

Depondt, C, Heinzen, EL, and Goldstein, DB. "Reply." Annals of Neurology 81, no. 1 (January 1, 2017): 161-162. (Letter) Full Text

Need, AC, Shashi, V, Schoch, K, Petrovski, S, and Goldstein, DB. "The importance of dynamic re-analysis in diagnostic whole exome sequencing." Journal of medical genetics (November 29, 2016). Full Text

McSweeney, KM, Gussow, AB, Bradrick, SS, Dugger, SA, Gelfman, S, Wang, Q, Petrovski, S, Frankel, WN, Boland, MJ, and Goldstein, DB. "Inhibition of microRNA 128 promotes excitability of cultured cortical neuronal networks." Genome research 26, no. 10 (October 2016): 1411-1416. Full Text

Petrovski, S, Küry, S, Myers, CT, Anyane-Yeboa, K, Cogné, B, Bialer, M, Xia, F, Hemati, P, Riviello, J, Mehaffey, M, Besnard, T, Becraft, E, Wadley, A, Politi, AR, Colombo, S, Zhu, X, Ren, Z, Andrews, I, Dudding-Byth, T, Schneider, AL, Wallace, G, Rosen, ABI, Schelley, S, Enns, GM, Corre, P, Dalton, J, Mercier, S, Latypova, X, Schmitt, S, Guzman, E, Moore, C, Bier, L, Heinzen, EL, Karachunski, P, Shur, N, Grebe, T, Basinger, A, Nguyen, JM, Bézieau, S, Wierenga, K, Bernstein, JA, and Scheffer, IE et al. "Germline De Novo Mutations in GNB1 Cause Severe Neurodevelopmental Disability, Hypotonia, and Seizures." The American Journal of Human Genetics 98, no. 5 (May 2016): 1001-1010. Full Text

Dhindsa, RS, and Goldstein, DB. "Schizophrenia: From genetics to physiology at last." Nature 530, no. 7589 (February 2016): 162-163. Full Text

Pages

Hafler, DA, Rao, A, Goodnow, CC, Abbas, AK, Wakeland, EK, Behrens, TW, Goldstein, DB, Kere, J, Cookson, W, Seed, B, Lindgren, C, Bowcock, A, Kuchroo, VK, Vyse, TJ, Wijmenga, C, and Wicker, LS. "Discussion." December 1, 2005.

Kertai, MD, Li, Y-W, Li, Y-J, Shah, SH, Kraus, WE, Fontes, ML, Stafford-Smith, M, Newman, MF, Podgoreanu, MV, and Mathew, JP. "G protein-coupled receptor kinase 5 gene polymorphisms are associated with postoperative atrial fibrillation after coronary artery bypass grafting in patients receiving β-blockers." Circulation. Cardiovascular genetics 7, no. 5 (October 2014): 625-633. Full Text

Interdisciplinary Training Program in Lung Disease awarded by National Institutes of Health (Preceptor). 2009 to 2020

Pathways From Maltreatment to Substance Abuse awarded by National Institutes of Health (Collaborator). 2010 to 2016

Statistical Models to Investigate Long-Distance QTL Transcription Regulation awarded by National Institutes of Health (Collaborator). 2011 to 2015

Identifying the Causes of Primary immunodeficiency through Next Generation Sequencing awarded by Baxter Healthcare Corporation (Collaborator). 2014 to 2015

Exploratory genomic investigations of mesial temporal lobe epilepsy awarded by National Institutes of Health (Co Investigator). 2012 to 2015

1/3-Identifying regulatory mutations that influence neuropsychiatric disease awarded by National Institutes of Health (Principal Investigator). 2014

Epilepsy Genetics Repository awarded by Citizens United for Research in Epilepsy (Principal Investigator). 2014

Unravelling the genetics of the common epilepsies using discordant monozygotic twins awarded by University of Melbourne (Principal Investigator). 2014

Identifying de novo mutations causing OCD in trios by whole exome sequencing awarded by National Institutes of Health (Principal Investigator). 2013 to 2014

1 of 2: Identification of Rare Variants of OCD awarded by National Institutes of Health (Principal Investigator). 2013 to 2014

Pages